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Charles Karsner Mills (1845-1931)
Charles K. Mills, a Philadelphian, made several
significant contributions to neurology: Administratively, he helped develop
the neurology service at the city's charity hospital, Philadelphia General
Hospital, and in 1877, directed the 20 bed unit for men and women inpatients.
One year later, the service expanded to 35 patients and by the early 1900's
the inpatient service numbered 400. Academically, he performed important
studies on aphasia and cortical localization patterns of parietal lobe
dysfunction. In 1886, he described alcohol-related polyneuropathy with
behavioral symptoms, preceding Koraskoff's work by one year. He described
unilateral progressive ascending paralysis due to degeneration of the
pyramidal tract in 1900, and the condition became known as "Mills' Syndrome".
He also described the clinical syndrome associated with unilateral occlusion
of the superior cerebellar artery. With poor vision and unable to read
for most of his adult life, he maintained a close surveillance of international
neurological issues, and was president of the American Neurological Association
twice, in 1886 and 1924 as its semicentennial leader.
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